Preparing Pandemic Vaccine Capacity

Among the challenges of a pandemic is the need to scale up to billions of doses, at a larger scale than typically needed for vaccines, from raw materials all the way through to the materials for the containers for fill/finish. Having adequate raw materials, building and staffing the facilities, and tech transfer are all keys to success. [...]we can plug into existing infrastructure, including services (gas, water, waste, etc.) as well as analytics and quality labs." Emergent BioSolutions says that its flexible CDMO capacity deployment model can respond quickly to demand fluctuations. The company's facilities in France, Switzerland, and the US are working on the project;at CordenPharma Colorado, unique high-pressure chromatography systems usually used for manufacturing peptides have been reallocated for purifying lipids.

Teaching civics/history and english to adult lawful permanent residents with limited english proficiency at local libraries: Challenges and practices during the COVID-19 pandemic

This chapter introduces a citizenship instruction program offered by the Teaching English to Speakers of Other Languages (TESOL) program at Oklahoma City University (OCU) in collaboration with two local libraries in the Oklahoma City metro area with a grant funded by the Institute of Museum and Library Services and the Oklahoma Department of Libraries. It specifically discusses the challenges that teachers and learners have encountered during the COVID-19 pandemic and the approaches utilized to address these challenges. Implications of this experience for instruction of civics/history and civics-based English, as well as the professionalization of ESL teachers, post-COVID-19 are discussed. © Springer Nature Switzerland AG 2021. All rights reserved.

TMS 2023 BACK TO BUSINESS AT TMS2023

With nearly 4,500 attendees gathered in San Diego CA, the TMS 2023 Annual Meeting & Exhibition (TMS2023) was the fourth best-attended meeting in TMS history, marking a return to business as usual (more or less) after two decidedly unusual years for the Society's biggest event. By comparison, approximately 2,600 individuals came together in person for TMS2022 in Anaheim CA. One year earlier, TMS2021--held as a fully virtual conference--attracted 2,967 attendees from around the world. This year's event, held Mar 19-23 in one of TMS's most popular meeting locations, brought the conference back closer to its pre-COVID participation numbers. The last time TMS met in San Diego was in 2020 (shortly before widespread pandemic shutdowns began) when more than 4,600 individuals came together for the largest meeting in the Society's history.

Supplements purchase intention: young consumer's perspective

PurposeThis study aims to investigate the factors that influence young consumers' purchase intention towards dietary supplements (DS) in Malaysia.Design/methodology/approachThe supplement industry in Malaysia has been growing rapidly recently due to a paradigm shift in healthcare management, from curative to prevention. Thus, it has sparked interest to conduct a study on the factors that influence young consumers' purchase intentions towards DS. With a response rate of 74.5%, a survey questionnaire was used to elicit data from 149 Gen-Y respondents who consume supplements on a regular basis.FindingsThe results revealed that the influencing factors towards purchase decisions among these Gen-Y respondents aged between 17 and 25 are based on product knowledge and product quality. The implications of these findings and directions for future research are outlined at the end of this paper.Originality/valueThis study offers empirical insights from the perspective of an emerging digital economy on the factors that influence young consumers' purchase intentions towards DS in Malaysia.

Connectivity, community, and sense of belonging

This chapter illustrates how the change to a virtual setting challenged students' social connectedness and sense of belonging. It demonstrates how students found a way to build social connectedness in a virtual setting that reinforced their sense of community. The chapter discusses how Students of Color experienced the COVID-19 interruption. It offers insights into whether thriving in college is even possible for students when their means of creating community have been disrupted. At the University of Utah, the detachment was experienced by students in their interactions with faculty and their relationships with their friends, peers, and classmates. The closing of campus and the shift to online learning also limited students' social connectedness with friends, classmates, and peers. Students also relied on new communities to gain motivation and achieve academically. University employees were also a part of students' relational communities. Some students created a strong emotional connection with staff members, such as advisors and student affairs professionals. The pandemic and the resulting educational changes added another layer of complexity to the academic experiences of Students of Color. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Stronger than partisanship and motivated reasoning: news exposure and news frames predicting US state-level preventive behaviours against COVID-19

The COVID-19 pandemic has become a partisan issue rather than an independent public health issue in the US. This study examined the behavioural consequences of motivated reasoning and framing by investigating the impacts of COVID-19 news exposure and news frames, as apparent through a Latent Dirichlet topic modelling analysis of local news coverage, on state-level preventive behaviours as understood through a nationally representative survey. Findings suggested that the media effects on various preventive behaviours differed. The overall exposure rate to all COVID-19 news articles increased mask-wearing but did not significantly impact other preventive behaviours. Four news frames significantly increased avoiding contact or avoiding public or crowded places. However, news articles discussing anxiety and stay at home order triggered resistance and countereffects and led to risky behaviours. ‘Solid Republican' state residents were less likely to avoid contact, avoid public or crowded places, and wear masks. However, partisan leanings did not interfere with the impact of differing local COVID-19 news frames on reported preventive behaviours. Plus, statements regarding pre-existing trust in Trump did not correlate with reported preventive behaviour. Attention to effect sizes revealed that news exposure and news frames could have a bigger impact on health behaviours than motivated reasoning.

Pandemic Challenges and Opportunities for Gender Equity in Clinical Research

In the arena of clinical research, gender equity accelerates research excellence: we need multiple perspectives and all the brain power we can muster to maximize research productivity and quality. [...]women physician investigators enhance enrollment of women as participants in clinical trials, which is crucial to our ability to generalize from the data and to maintain the health of women. Women are underrepresented among academic grand rounds speakers,14 speakers at medical conferences15, and award recipients from medical specialty societies.16 Time pressure is especially intense on young women faculty. Besides spending more time on domestic chores, they spend more time at work on teaching, service, and mentoring. Female primary care physicians spend more time with patients.22 Elderly hospitalized patients treated by female internists experience lower mortality and readmission rates.23 Patients undergoing coronary artery bypass grafting had shorter hospital length of stay when treated by an all-female physician team as compared with an all-male team.24 Female patients treated by male physicians following acute myocardial infarction have higher mortality than those treated by female physicians.25 Sex discordance between patient and surgeon is associated with increased likelihood of adverse postoperative outcomes-and that observation that is driven by worse outcomes for female patients treated by male physicians.26 Clinical trials play a fundamental role in bringing new medications and interventions to our patients, yet women have often been excluded from participation. Among 60 randomized controlled trials (RCTs) of lipidlowering therapies reported between 1990 and 2018, there was a modest increase in enrollment of women over time, but women remain underrepresented compared with the relative burden of disease.30 In another study of 317 RCTs of heart failure with reduced ejection fraction published in highimpact journals over the past 20 years, only 25% of participants overall were female, and females were under-enrolled in 72% of these trials.

Social Distance with Tourists in U.S. Counties with the Highest Historical Numbers of Reported COVID-19 Cases

With destinations steadily ‘opening back up for business' (while COVID-19 cases are still high in many areas), there is an increasing need to consider residents. Integrating the cognitive appraisal theory and the affect theory of exchange, this work tests a structural model examining the degree to which residents' perceptions of COVID-19 precautionary measures explain emotions directed toward visitors, and ultimately their willingness to engage in shared behaviors with tourists. Data were collected from 530 residents in 25 U.S. counties with the highest percentages of historical COVID-19 cases per population. A total of 10 of the 12 tested hypotheses were significant, contributing to 60% and 85% of the variance explained in contending and accommodating emotions, and 53% and 50% of the variance explained in engaging in less intimate–distal and more intimate–proximal behaviors with tourists. The implications highlight the complementary use of the two frameworks in explaining residents' preference for engagement in less intimate–distal interactions with tourists.

Being a product consumer during the COVID-19 pandemic: profile of the Polish consumer in the organic dairy market

PurposeThe purpose of this paper was to determine the profile of dairy product consumers in the organic market.Design/methodology/approachThe study was based on a survey questionnaire developed by the author and administered to a total of 1,108 respondents. The statistical analysis (including descriptive statistics, the analysis of the discriminative function and the Chi2 test was performed with the use of Statistica 13.1 PL. The respondents' gender was the factor behind the differences in how they behaved.FindingsThe consumers indicated the channels they rely upon to find information on organic dairy products;in addition to trusting the opinions of their family members and experts, they also use web platforms. Further, they specified their preferred locations for buying favorite products during the pandemic: specialized organic food shops, large distribution chains and online stores.Practical implicationsThese outcomes will help in identifying target consumer segments and information channels for specific information and advertising messages. They also form an important resource for developing some potential strategies which the supply chain stakeholders could implement to promote organic consumption of dairy products.Originality/valueThis study identifies consumers' preferred dairy products;motives for purchasing organic dairy products;barriers that consumers believe exist in the market;sources of knowledge about products purchased by consumers;and consumers' preferred channels for purchasing organic dairy products. To the best of the author's knowledge, this is the first study of dairy product consumers in the organic market in Poland.

Vaccine Hesitancy Among African Americans

The limited participation of African Americans in clinical trials has been a topic of discussion among medical and scientific researchers for some time. With the testing of coronavirus vaccines, this discussion has continued, particularly given the disproportionate impact of the virus on members of the African American community. With the public health goal of achieving widespread or "herd" immunity, the concept of "vaccine hesitancy" has also been addressed with regard to the population in general, and in relation to the African American community, among others. Vaccine hesitancy has been reported among groups from healthcare workers to rural residents to the poor. As is the case with all segments of society, African Americans are not monolithic. However, there are aspects of the issue of vaccine hesitancy which are unique and specific to the African American community in the U.S. In particular, the nature of the information about the coronavirus itself and about the vaccine, and importantly, the increasing availability of the information about the Tuskegee experiment, Henrietta Lacks, and other cases, along with the prevalence of misinformation and disinformation on aspects of science, such as that involving vaccines, are relevant to understanding the nature of vaccine hesitancy among African Americans.

Examining perceived levels of stress, burnout, and job satisfaction among play therapists

Work-related stress and burnout have become a popular topic for research studies over the course of many years. The COVID-19 pandemic has also highlighted the importance of monitoring stress and well-being for workers in a variety of fields. The purpose of the present study was to examine the relationship between perceived stress, burnout, and job satisfaction among play therapists. We found a strong correlation between perceived stress and burnout among sample participants. We also found a strong negative relationship between these variables and job satisfaction. Based on our findings, we recommend several strategies that supervisors can implement when working with counselors-in-training in order to prevent stress and burnout for this specific therapist population. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Turnover Intention Model: Self- Determination Theory Approach: Acces la Success

The purpose of this study is to examine and analyze the influence of mental workload and person-organization fit on turnover intention, using basic psychological needs frustration (BPNF) as the intervening variable in the hospital in Daerah Istimewa Yogyakarta. The sample of this study is vocational nurse in the hospital in Daerah Istimewa Yogyakarta. The sample is carried out through survey from 153 respondents, which is processed using Structural Equation Modeling (SEM) method. This study finds that mental workload does not have direct influence on turnover intention, but it is mediated (full mediation) by need for competence frustration and need for relatedness frustration. Person-organization fit has a positive influence on need for autonomy frustration. However, person-organization fit does not have an influence on turnover intention, and basic psychological needs does not mediate the relationship of these variables. This study also found that the category of mental workload is quite low, person-organization fit is low, basic psychological needs frustration is quite low, and turnover intention is low. Nurse has the extrinsic motivation of identified regulation, thus hospital leaders should bring their motivation from identified regulation to intrinsic motivation, through internalization by establishing supportive work environment, namely Islamic spiritual workplace (ISW), with basic psychological needs supporting in each of its dimension. This study is expected to be a reference for practitioners in human resource management, especially regarding human resource retention function through the implementation of ISW. ISW contributes to lower mental workload, the increase of person-organization fit, establishment of basic psychological need satisfaction, as well as the decrease of basic psychological needs frustration and turnover intention.

DIVERSITY IN CLINICAL TRIALS GAINS GROUND AMIDST COVID

More recent policies aim to offset years of underenrollment of minority groups by expanding enrollment criteria, including more research sites in minority communities, and engaging investigators with diverse backgrounds. FDA has also sought to promote research diversity through its Drug Trials Snapshots program, established in 2015 to increase the visibility of clinical trial enrollment by age, sex, ethnicity and race. According to a recent report on the program's impact, though, there still may be a ways to go for clinical trials to reflect the diversity of the US population.

DEBATE ACCELERATES OVER WHO GETS COVID VACCINE FIRST

At the agencies' request, the National Academy of Sciences, Engineering and Medicine iNASEMi has formed a blue-ribbon committee of leading bioethicists, economists, geneticists, and public health authorities to quickly develop a framework for priority vaccine access to assist policymakers in the U.S. and other nations achieve equitable distribution of anticipated vaccines (see: https://bit.ly/33jTCds). Individuals at higher risk will include those in higher age groups, with underlying health conditions, engaged in high-risk occupations, affected by racial and ethnic disparities, and in hardhit geographic locations. State and public health officials are wary of federal pandemic planning efforts so fair given the lack of coordination and effectiveness in distributing COVID-19 test kits and personal protective equipment to healthcare providers and facilities.

COVID ADVANCES CLINICAL TRIAL TRANSPARENCY

Growing public concerns about politics playing a role in vetting potential vaccines and therapies to combat the COVID-19 pandemic has prompted sponsors of leading clinical trials to make public their study protocols and statistical analysis plans. [...]AstraZeneca's timeframe for enrolling and assessing study participants was delayed by the need to address the report of a serious adverse event in its Phase III study. The disclosure of these usually confidential details on research endpoints, assessment timeframes, and study analysis plans aim to promote information sharing among vaccine developers, and also build public confidence.

CLINICAL TRIAL REFORM

[...]CURES' BILL PROMOTES PANDEMIC PREPAREDNESS Congressional leaders are developing the next version of the 21st Century Cures Act, including provisions to advance research related to the COVID-19 crisis as part of initiatives for bringing innovative therapies to market faster (see https://bit.ly/2SKfA4S). Cures 2.0 continues and updates some of the main themes of the first Cures Act: support development of treatments for rare diseases, patient-focused drug development, diversity in clinical trials, expanded use of digital health systems, increased health literacy, and utilization of real-world data. A public education campaign, moreover, would aim to counter concerns about the safety of vaccines to promote widespread vaccination. Because these treatments are costly and unprofitable for biopharma companies to test and market, the legislation proposes additional financial support for both pre-market studies and post-market production and subsidized higher reimbursement rates for antibiotics that address critical needs.

Lack of efficacy of hydroxychloroquine in covid-19

Studies in mild-to-moderate cases as well as severe disease leave us still searching for a magic pill

The impact of the COVID-19 pandemic on the healthcare of patients with type 2 diabetes mellitus in the department of veterans affairs

The novel coronavirus (COVID-19) pandemic and strategies meant to mitigate infections caused disruptions to healthcare services across the globe. To evaluate the impact of the COVID-19 pandemic on the healthcare of patients with type 2 diabetes in the VA healthcare system, this work enumerated a cohort of patients with type 2 diabetes who utilized care in the VA across all months between March 2018 and February 2022 and analyzed service utilization, medication adherence, and diabetes-related short-term outcomes.The first objective was to determine the effect of the pandemic's interruption on the utilization of diabetes-related outpatient encounters. Results showed that the share of patients with diabetes with at least one virtual care visit increased from 3.4% in the pre- COVID year (March 2019 to February 2020) to 16.4% in the first year during COVID (March 2020 to February 2021) while the percent of patients with diabetes with an in- person diabetes-related outpatient visit fell from 89.8% to 72.3%.Second, large changes in oral antidiabetic medication use, adherence (i.e., proportion of days (PDC) covered >=80%), and discontinuation (zero days covered) were discovered during the pandemic among patients with treated type 2 diabetes. The mean percent adherent was 23.4%, 11.6%, and 30.1% during the pre-pandemic (i.e., March 2018-February 2020), pre-vaccine pandemic (i.e., March 2020-December 2020), and post-vaccine pandemic (i.e., January 2021-February 2020) periods, respectively.Finally, this study evaluated changes in average A1C measurement, glycemic control, and preventable diabetes outcomes before and during the COVID-19 pandemic. The percent of eligible patients with A1C measurement decreased by 8.6% when the pandemic began, trending back to pre-pandemic levels by January 2021, at which point it fell by about 1% per month to end of study. The rate of uncontrolled diabetes averaged 400 per 100,000 before the pandemic, but rose to almost 550 per 100,000 patients during the pandemic. Likewise, the rate of short-term complications averaged 30 per 100,000, but rose to 49 per 100,000 at its high during the pandemic.The pandemic's interruptions caused vast differences in the healthcare routines of patients with diabetes, which initially led to more negative outcomes than before the pandemic. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Preparing special education intern teachers remotely during the COVID-19 pandemic

The purpose of this qualitative case study was to investigate the effectiveness of remote teacher preparation during the COVID-19 pandemic, specifically special education teachers participating at an Intern Credentialing Program in Northern California.In addition to remote teacher preparation, the study explored how intern teachers experienced delivering special services remotely, how they perceived the Intern Program prepared them compared to traditional programs, and how they experienced their preparation to become agents of change in public education. Data for this study was collected through field journals, surveys and interviews. The findings of this study revealed that Intern Teachers experienced remote Teacher Education as having more benefits than challenges, however the delivery of services to students with disabilities had more challenges than benefits. The interviews indicated that the Intern Teachers believe they are not well prepared to be agents of change.Implications of the study include recommendations to continue teacher education remotely, to develop a tool to determine student benefit from delivery of special services remotely, and to add to teacher education programs curriculum and activities that support diversity, inclusion, and belonging in the classroom through the frameworks of Emancipatory Pedagogies, Critical Race Theory, Culturally Relevant Pedagogy, Culturally Sustaining Pedagogy and Discrit. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

The burnout warning

This chapter covers three distinct themes that encompass the concept of burnout warning: inherent adversities in the modality shift, fear and ambiguity in higher education, and attempting to work in suboptimal conditions. While thriving represents a concept that denotes success and achievement, burnout represents exhaustion and fatigue. The behavior exhibited by staff and its correlation to burnout is best explained by the works of Maslach and Leiter using the areas of worklife (AW) model entailing organizational risk factors. The AW model explains how burnout is expedited when there is a disruption to balance in the following areas: workload, control, reward, community, fairness, and values. The findings indicate that staff members at the University of Utah displayed early signs of burnout warning. The factors that contribute to early signals of burnout include resource shortages, an increase in overall workload-including persistent emotional labor-and a lack of acknowledgement. The chapter illustrates how stressors, aggravated by COVID fatigue, fostered an environment that mobilized the onset of burnout. (PsycInfo Database Record (c) 2023 APA, all rights reserved)